Switching RNA Interference

Description

The project aims at the development of novel tools for triggering RNA interference (RNAi) that will allow for enhanced control of the phenomenon. RNAi describes the specific down-regulation of gene expression induced by homologous double-stranded RNAs, exploiting a naturally occurring pathway. Although it has been discovered recently, the technique has already become a valuable tool in modern biological sciences for controlling gene expression in eukaryotes. Moreover, RNA interference shows promising potential for therapy of a variety of clinical pictures. Tthe possibility to switch on and off RNAi by other nucleic acids, proteins, and small, drug-like molecules will be explored. In addition to the modulation of RNA interference by controlling siRNA activity, regulation could be achieved by localizing the effects.

Participants
Institutions
  • Department of Chemistry
  • Zukunftskolleg
  • Graduiertenschule Chemical Biology
Funding sources
Name Finanzierungstyp Kategorie Project no.
Volkswagen-Stiftung third-party funds research funding program 575/06
Further information
Period: 20.01.2006 – 31.12.2011