NMR assignment and characterization

Description

The Na+-NQR is a large membrane-bound protein complex composed of six subunits which plays a pivotal role in the energy metabolism of the human pathogen Vibrio cholerae. Driven by oxidation of NADH it generates an electrochemical Na+ gradient across the membrane. Its 3D structure is still unknown as is the mechanism by which NADH oxidation is coupled to sodium translocation. The long-term goal of this research project is to characterize structure, dynamics and function of Na+-NQR in collaboration with Prof. J. Steuber, University of Hohenheim, by combining molecular and cell biology techniques with NMR spectroscopy and X-ray crystallography.

Institutions
  • FB Chemie
Funding sources
Name Project no. Description Period
Exzellenzinitiative800/09no information
Further information
Period: 01.12.2009 – 31.10.2012